📚 Syllabus & Course Curriculum
Drug Discovery & Pharmaceutical Sciences
Module-by-module breakdown of Organoids & 3D Culture Models for Drug Screening, from foundations to a certified capstone project.
Systems
• Spheroids, organoids, organ-on-chip and explants — what each can answer
• Adult stem cell against iPSC-derived organoids and their differing maturity
• What 3D culture does not model: vasculature, immune cells, systemic exposure
Culture
• Tissue dissociation, embedding and the niche factors each organ type requires
• Matrigel lot variability and the move toward defined synthetic matrices
• Passaging, cryopreservation and drift over extended culture
Characterisation
• Marker expression, histology and comparison against the parent tissue
• Functional assays such as forskolin swelling for genuine physiological readout
• Authentication and mycoplasma testing as basic and frequently skipped hygiene
Screening
• Dose-response design and replicate structure in an expensive 3D format
• Hepatotoxicity and nephrotoxicity models and their predictive performance
• Combination screening and the rapid growth of the plate count
Disease
• Biobanks of patient-derived organoids for disease and mutation studies
• The FDA Modernization Act and the standing of non-animal models
• Reproducibility problems that keep organoids out of regulated toxicology
Earn government-registered certification in Organoids & 3D Culture Models for Drug Screening
e-Certificate and e-Marksheet issued on successful completion.
