Programme Parameters
Graduate / Intermediate
4 Weeks (40 Hrs)
Online (e-LMS)
• A basic understanding of the subject area and fundamental programming or scientific concepts.
• A laptop or desktop with a stable internet connection.
• Willingness to complete assignments and the capstone project.
About This Course
Liquid Biopsy and Circulating Biomarker Analysis explores a minimally invasive revolution in diagnostics: reading disease from a simple blood draw. You learn the biology of circulating biomarkers — circulating tumour DNA, circulating tumour cells, and extracellular vesicles — and the sensitive methods used to detect and analyse them. The course connects these to real clinical uses in oncology: early detection, monitoring treatment response and resistance, and guiding precision therapy, alongside the sensitivity and standardisation challenges the field faces. You finish able to reason about a liquid-biopsy approach to a clinical question. A verified e-Certificate of competency and e-Marksheet from the Deep Science & Technology Consortium.
🎯 Program Aim
This course covers liquid biopsy — analysing circulating tumour DNA, cells and other biomarkers in blood for cancer detection, monitoring and precision oncology.
📋 Course Objectives
1. Explain circulating biomarkers: ctDNA, CTCs and vesicles.
2. Describe methods to detect and analyse them.
3. Apply liquid biopsy to detection and monitoring.
4. Connect biomarkers to precision oncology.
5. Assess sensitivity and standardisation challenges.
👥 Who Should Enroll?
• Oncology and molecular-diagnostics researchers
• Clinical and pathology professionals
• Biotech and diagnostics R&D staff
• Students of biomedical science
🚀 Key Learning Outcomes
• An understanding of liquid-biopsy science.
• The ability to reason about a diagnostic approach.
• A foundation in precision oncology.
• A verified e-Certificate of competency and e-Marksheet from the Deep Science & Technology Consortium.
💎 What You'll Gain
Live & Recorded Sessions
Lifetime access to class recordingse-Certificate on Completion
Cryptographically verified credentialPost-Programme Support
Direct access to mentors & councilHands-On Experience
Notebooks, real-world code & datasetsCurriculum Outline
Foundations of Liquid Biopsy And Circulating Biomarker Analysis and Core Biological Principles
Analyze the fundamental principles of liquid biopsy and circulating biomarker analysis, including the biology of circulating tumor DNA and RNA • Evaluate the clinical applications and limitations of liquid biopsy in cancer diagnosis and treatment monitoring • Develop a comprehensive understanding of the core biological principles underlying liquid biopsy and circulating biomarker analysis, including epigenetics and gene expression
Laboratory Techniques, Protocols, and Data Collection
Configure and optimize laboratory protocols for the collection and processing of liquid biopsy samples, including plasma and urine • Implement quality control measures to ensure the integrity and reliability of laboratory data • Design and develop standardized operating procedures for the handling and analysis of liquid biopsy samples
Bioinformatics Tools and Computational Analysis
Apply bioinformatics tools and pipelines to analyze and interpret liquid biopsy data, including next-generation sequencing and machine learning algorithms • Develop and implement computational models to predict biomarker performance and identify potential biases • Evaluate the strengths and limitations of various bioinformatics tools and pipelines for liquid biopsy data analysis
Research Methodology and Experimental Design
Design and develop experimental protocols for the validation and verification of liquid biopsy biomarkers • Analyze and interpret the results of liquid biopsy studies, including the assessment of sensitivity, specificity, and accuracy • Develop and implement strategies for the optimization of liquid biopsy assay performance and the minimization of errors
Advanced Liquid Biopsy And Circulating Biomarker Analysis Applications and Translational Research
Investigate the applications of liquid biopsy in precision medicine, including personalized cancer treatment and monitoring • Evaluate the potential of liquid biopsy to enable early cancer detection and diagnosis • Develop and implement strategies for the translation of liquid biopsy research into clinical practice
Regulatory Compliance, Bioethics, and Safety Standards
Analyze the regulatory frameworks and guidelines governing the development and use of liquid biopsy tests • Evaluate the bioethical implications of liquid biopsy research and testing, including issues related to informed consent and patient privacy • Develop and implement strategies for ensuring compliance with regulatory requirements and safety standards in liquid biopsy research and testing
Industry Applications, Career Pathways, and Case Studies
Investigate the applications of liquid biopsy in various industries, including pharmaceuticals and biotechnology • Evaluate the career pathways and opportunities available to professionals in the field of liquid biopsy and circulating biomarker analysis • Analyze case studies of successful liquid biopsy research and development projects, including the challenges and opportunities encountered
Technical Specifications
| Parameter | Requirement |
|---|---|
| Covered Tool / Platform | Python |
| Covered Tool / Platform | TensorFlow |
| Covered Tool / Platform | next-generation sequencing |
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