How the genome is switched on and off โ beyond the DNA sequence.
Biotechnology & Genetic Engineering
Module-by-module breakdown of Epigenetic Mechanisms in Gene Regulation, from foundations to a certified capstone project.
Outline
Analyze the molecular mechanisms underlying epigenetic regulation, including DNA methylation and histone modification โข Develop a comprehensive understanding of the core biological principles governing gene expression, including transcriptional regulation and chromatin remodeling โข Evaluate the role of epigenetic mechanisms in shaping cellular identity and responding to environmental cues
Outline
Configure and optimize laboratory equipment for epigenetic assays, including chromatin immunoprecipitation sequencing (ChIP-seq) and bisulfite sequencing โข Implement standardized protocols for sample preparation, data collection, and quality control in epigenetic research โข Design and execute experiments to investigate epigenetic mechanisms, including the use of CRISPR-Cas9 genome editing and single-cell analysis
Outline
Apply bioinformatics tools, such as Bowtie and SAMtools, to analyze high-throughput sequencing data and identify epigenetic marks โข Develop and implement computational pipelines to integrate and analyze multi-omics data, including genomics, transcriptomics, and proteomics โข Evaluate the performance of different bioinformatics tools and algorithms for epigenetic data analysis, including machine learning and deep learning approaches
Outline
Design and propose experimental studies to investigate epigenetic mechanisms, including the development of hypotheses, research questions, and study objectives โข Develop and implement robust experimental designs, including the use of controls, replicates, and randomization โข Evaluate and refine research methodologies, including the use of power analysis, sample size calculation, and statistical modeling
Outline
Investigate the role of epigenetic mechanisms in human disease, including cancer, neurological disorders, and metabolic disorders โข Develop and apply epigenetic therapies, including the use of epigenetic editing tools and small molecule inhibitors โข Evaluate the potential of epigenetic biomarkers for disease diagnosis, prognosis, and monitoring
Outline
Comply with regulatory requirements and guidelines for epigenetic research, including the use of human subjects and animal models โข Apply bioethical principles to epigenetic research, including the consideration of informed consent, privacy, and beneficence โข Develop and implement laboratory safety protocols, including the use of personal protective equipment and hazardous waste disposal
Outline
Explore industry applications of epigenetic research, including the development of epigenetic therapies and diagnostics โข Develop career pathways and professional development plans for epigenetic researchers, including the pursuit of funding and publication โข Evaluate case studies of successful epigenetic research and its translation to clinical and industrial applications
e-Certificate and e-Marksheet issued on successful completion.