📚 Syllabus & Course Curriculum
Immunology & Vaccine Development
Module-by-module breakdown of Advancements in mRNA Vaccine Technology, from foundations to a certified capstone project.
Design
• Cap, UTRs, coding sequence and poly-A tail and the function of each
• Codon optimisation and GC content effects on expression and stability
• Nucleoside modification with N1-methylpseudouridine and why it was decisive
Manufacture
• IVT reaction, capping strategies and enzymatic against co-transcriptional capping
• Double-stranded RNA impurities and their removal as a critical quality step
• Purification, fill-finish and the analytical release panel
Delivery
• Ionisable lipid, helper lipid, cholesterol and PEG-lipid roles
• Microfluidic formulation and the parameters controlling particle size
• Cold chain requirements and the stability work aimed at removing them
Immunology
• Antigen expression, presentation and the resulting T and B cell responses
• Innate sensing, reactogenicity and the trade-off against immunogenicity
• Durability, waning and the evidence base behind boosting intervals
Frontier
• Self-amplifying and circular mRNA and their claimed dose advantages
• Personalised cancer neoantigen vaccines and the manufacturing timeline problem
• Protein replacement therapy and the redosing challenge it faces
Earn government-registered certification in Advancements in mRNA Vaccine Technology
e-Certificate and e-Marksheet issued on successful completion.
