Programme Parameters
Graduate / Intermediate
3 Days (4.5 Hrs)
Online (e-LMS)
• A basic understanding of the subject area and fundamental programming or scientific concepts.
• A laptop or desktop with a stable internet connection.
• Willingness to complete assignments and the capstone project.
About This Course
This three-day intensive course dives into the revolutionary world of mRNA vaccine technology, which has shown remarkable success in rapid vaccine development, notably during the COVID-19 pandemic. Participants will explore the fundamental aspects of mRNA vaccine structure, delve into the advanced techniques of vaccine manufacturing, and discuss the future landscape of mRNA technologies in therapeutics and beyond. Every participant receives a verified e-Certificate and e-Marksheet from the Deep Science & Technology Consortium.
🎯 Program Aim
This three-day intensive course dives into the revolutionary world of mRNA vaccine technology, which has shown remarkable success in rapid vaccine development, notably during the COVID-19 pandemic. Participants will explore the fundamental aspects of mRNA vaccine structure, delve into the advanced techniques of vaccine manufacturing, and discuss the future landscape of mRNA technologies in therapeutics and beyond.
📋 Course Objectives
1. Apply biotechnology methods to authentic research and industry problems.
2. Produce a reproducible, portfolio-ready project you can cite in a thesis, paper, or job application.
👥 Who Should Enroll?
• Master's and senior undergraduate students specializing in biotechnology
• R&D engineers and working professionals applying biotechnology in industry
• Academics and educators building research or teaching capacity in biotechnology
🚀 Key Learning Outcomes
• Tangible, reproducible biotechnology work to show supervisors or employers.
• A verified e-Certificate of competency and e-Marksheet from the Deep Science & Technology Consortium.
💎 What You'll Gain
Live & Recorded Sessions
Lifetime access to class recordingse-Certificate on Completion
Cryptographically verified credentialPost-Programme Support
Direct access to mentors & councilHands-On Experience
Notebooks, real-world code & datasetsCurriculum Outline
Constructing the mRNA
• Cap, UTRs, coding sequence and poly-A tail and the function of each
• Codon optimisation and GC content effects on expression and stability
• Nucleoside modification with N1-methylpseudouridine and why it was decisive
In Vitro Transcription at Scale
• IVT reaction, capping strategies and enzymatic against co-transcriptional capping
• Double-stranded RNA impurities and their removal as a critical quality step
• Purification, fill-finish and the analytical release panel
Lipid Nanoparticles
• Ionisable lipid, helper lipid, cholesterol and PEG-lipid roles
• Microfluidic formulation and the parameters controlling particle size
• Cold chain requirements and the stability work aimed at removing them
How the Response Is Generated
• Antigen expression, presentation and the resulting T and B cell responses
• Innate sensing, reactogenicity and the trade-off against immunogenicity
• Durability, waning and the evidence base behind boosting intervals
Beyond Infectious Disease
• Self-amplifying and circular mRNA and their claimed dose advantages
• Personalised cancer neoantigen vaccines and the manufacturing timeline problem
• Protein replacement therapy and the redosing challenge it faces
Technical Specifications
| Parameter | Requirement |
|---|---|
| Covered Tool / Platform | NCBI Tools |
| Covered Tool / Platform | BLAST |
| Covered Tool / Platform | PyMOL |
| Covered Tool / Platform | AutoDock |
| Covered Tool / Platform | ChemDraw |
| Covered Tool / Platform | Clustal Omega |
| Covered Tool / Platform | Python |
Frequently Asked Questions
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