Programme Parameters
Advanced Postgrad
3 Days (4.5 Hrs)
Online (e-LMS)
• Prior working knowledge of the field and comfort with core tools and quantitative reasoning.
• A laptop or desktop with a stable internet connection.
• Willingness to complete assignments and the capstone project.
About This Course
Single Nucleotide Polymorphisms (SNPs) are critical genetic variations that play significant roles in disease research, personalized medicine, and population genetics. This course offers an in-depth exploration of SNP detection and analysis using NGS technologies. Participants will learn the principles of SNP identification, the technical aspects of NGS platforms, and the bioinformatics tools required for data analysis. Every participant receives a verified e-Certificate and e-Marksheet from the Deep Science & Technology Consortium.
🎯 Program Aim
Single Nucleotide Polymorphisms (SNPs) are critical genetic variations that play significant roles in disease research, personalized medicine, and population genetics. This course offers an in-depth exploration of SNP detection and analysis using NGS technologies. Participants will learn the principles of SNP identification, the technical aspects of NGS platforms, and the bioinformatics tools required for data analysis.
📋 Course Objectives
1. Put biotechnology techniques to work on real datasets and case studies.
2. Build a defensible project you can showcase to supervisors, reviewers, or employers.
👥 Who Should Enroll?
• Master's and senior undergraduate students specializing in biotechnology
• R&D engineers and working professionals applying biotechnology in industry
• Academics and educators building research or teaching capacity in biotechnology
🚀 Key Learning Outcomes
• A portfolio-grade biotechnology deliverable you can defend and extend.
• A verified e-Certificate of competency and e-Marksheet from the Deep Science & Technology Consortium.
💎 What You'll Gain
Live & Recorded Sessions
Lifetime access to class recordingse-Certificate on Completion
Cryptographically verified credentialPost-Programme Support
Direct access to mentors & councilHands-On Experience
Notebooks, real-world code & datasetsCurriculum Outline
Introduction to NGS Technology
Understand Next-Generation Sequencing principles • Explore various NGS data formats and their applications • Access and download NGS data using SRA toolkit
Data Quality Control and Preprocessing
Check sequence quality using FastQC • Clean sequences using cutadapt • Align sequences using BWA • Sort the BAM alignment files
Variant Detection and Analysis
Mark PCR duplicates in BAM alignment files using Picard • Identify variants (SNPs and indels) using FreeBayes and Delly • Visually inspect read mapping and variant calls with IGV
Advanced SNP Analysis Techniques
Filter and annotate variants using specialized tools • Perform population genetics analysis • Conduct pathway analysis of significant SNPs
SNP Applications in Research and Medicine
Explore SNP applications in genomics research • Study pharmacogenomics and personalized medicine • Analyze SNPs in evolutionary biology studies
Technical Specifications
| Parameter | Requirement |
|---|---|
| Covered Tool / Platform | SRA Toolkit |
| Covered Tool / Platform | FastQC |
| Covered Tool / Platform | cutadapt |
| Covered Tool / Platform | BWA |
| Covered Tool / Platform | Picard |
| Covered Tool / Platform | FreeBayes |
| Covered Tool / Platform | Delly |
| Covered Tool / Platform | IGV |
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