📚 Syllabus & Course Curriculum
Data Science & Analytics
Module-by-module breakdown of Prediction of Peptide’s Secondary, Tertiary Structure and Their Properties Using Online Tools, from foundations to a certified capstone project.
Chemistry
• Amino acid properties and the noncovalent interactions that drive folding
• Phi and psi angles, the Ramachandran plot and disallowed conformations
• Why short peptides are often disordered rather than folded at all
Properties
• ProtParam for molecular weight, pI, extinction coefficient and instability index
• Hydrophobicity scales, amphipathicity and helical wheel analysis
• Solubility and aggregation prediction before a peptide is ever ordered
Secondary
• PSIPRED and JPred for helix, strand and coil assignment
• Disorder prediction with IUPred and its biological meaning
• Transmembrane and signal peptide prediction with TMHMM and SignalP
Tertiary
• PEP-FOLD and AlphaFold applied to short sequences, and their weaknesses
• Confidence scores on peptides and why they run low for good reason
• Cyclic and modified peptides that standard tools cannot handle
Function
• Antimicrobial and cell-penetrating peptide prediction servers
• Stability, protease susceptibility and half-life considerations
• CD spectroscopy as the experimental check on a predicted secondary structure
Earn government-registered certification in Prediction of Peptide’s Secondary, Tertiary Structure and Their Properties Using Online Tools
e-Certificate and e-Marksheet issued on successful completion.
