📚 Syllabus & Course Curriculum
Drug Discovery & Pharmaceutical Sciences
Module-by-module breakdown of Computer Aided Drug Design in Taste Masking (CADD), from foundations to a certified capstone project.
Perception
• TAS2R bitter receptor family and the promiscuity of individual receptors
• BitterDB and the structure-activity patterns behind bitter drug molecules
• Why patient adherence, particularly paediatric, makes this a formulation priority
Prediction
• BitterPredict and similar classifiers, and their limited chemical space
• Molecular descriptors that correlate with bitterness, and the ones that only appear to
• Homology models of TAS2Rs and the caution required with docking into them
Complexation
• Beta-cyclodextrin inclusion complexes and host-guest geometry
• Molecular docking and MD to estimate binding and complexation stability
• Phase solubility studies as the experimental check on the computed prediction
Formulation
• Ion exchange resinates, polymer coating and lipid barriers compared
• Prodrug and salt selection where the molecule permits it
• Release requirements that a masking approach must not compromise
Evaluation
• Electronic tongue measurement and its correlation with human panels
• In vitro dissolution in simulated saliva as a screening assay
• Human taste panel design, ethics approval and the limits of small panels
Earn government-registered certification in Computer Aided Drug Design in Taste Masking (CADD)
e-Certificate and e-Marksheet issued on successful completion.
