📚 Syllabus & Course Curriculum
Drug Discovery & Pharmaceutical Sciences
Module-by-module breakdown of Advanced Drug Designing: Traditional and In Silico, from foundations to a certified capstone project.
Medicinal Chemistry
• Structure-activity relationships and bioisosteric replacement
• Lipinski and beyond: property-based design and ligand efficiency metrics
• Hit, lead and candidate stages and the decisions at each gate
Structure-Based
• Target preparation, protonation states and binding-site definition
• Molecular docking, scoring function limitations and pose plausibility
• Structure-based optimisation guided by interaction analysis
Ligand-Based
• Pharmacophore modelling and shape-based screening
• QSAR with a defined applicability domain
• Similarity searching and scaffold hopping
Dynamics
• Molecular dynamics for stability and induced fit
• Binding free energy estimation and its cost-accuracy trade-off
• Interpreting simulation results without overclaiming
ADMET
• ADMET prediction and the endpoints where models remain unreliable
• Toxicity alerts, off-target liabilities and hERG risk
• Why compounds fail late, and what earlier analysis could have caught
Earn government-registered certification in Advanced Drug Designing: Traditional and In Silico
e-Certificate and e-Marksheet issued on successful completion.
