Programme Parameters
Graduate / Intermediate
4 Weeks (40 Hrs)
Online (e-LMS)
• A basic understanding of the subject area and fundamental programming or scientific concepts.
• A laptop or desktop with a stable internet connection.
• Willingness to complete assignments and the capstone project.
About This Course
The Computer-Aided Drug Design in Taste Masking (CADD) program integrates computational methods with pharmaceutical science to tackle the challenge of improving the taste of medications. Leveraging advanced modeling techniques, participants delve into the intricate molecular structures of drugs, aiming to design formulations that effectively mask their bitter taste. Every participant receives a verified e-Certificate and e-Marksheet from the Deep Science & Technology Consortium.
🎯 Program Aim
The Computer-Aided Drug Design in Taste Masking (CADD) program integrates computational methods with pharmaceutical science to tackle the challenge of improving the taste of medications. Leveraging advanced modeling techniques, participants delve into the intricate molecular structures of drugs, aiming to design formulations that effectively mask their bitter taste.
📋 Course Objectives
1. Apply biotechnology methods to authentic research and industry problems.
2. Build a defensible project you can showcase to supervisors, reviewers, or employers.
👥 Who Should Enroll?
• Master's and senior undergraduate students specializing in biotechnology
• R&D engineers and working professionals applying biotechnology in industry
• Academics and educators building research or teaching capacity in biotechnology
🚀 Key Learning Outcomes
• Tangible, reproducible biotechnology work to show supervisors or employers.
• A verified e-Certificate of competency and e-Marksheet from the Deep Science & Technology Consortium.
💎 What You'll Gain
Live & Recorded Sessions
Lifetime access to class recordingse-Certificate on Completion
Cryptographically verified credentialPost-Programme Support
Direct access to mentors & councilHands-On Experience
Notebooks, real-world code & datasetsCurriculum Outline
The Biology of Bitterness
• TAS2R bitter receptor family and the promiscuity of individual receptors
• BitterDB and the structure-activity patterns behind bitter drug molecules
• Why patient adherence, particularly paediatric, makes this a formulation priority
Modelling Taste Computationally
• BitterPredict and similar classifiers, and their limited chemical space
• Molecular descriptors that correlate with bitterness, and the ones that only appear to
• Homology models of TAS2Rs and the caution required with docking into them
Cyclodextrins and Molecular Encapsulation
• Beta-cyclodextrin inclusion complexes and host-guest geometry
• Molecular docking and MD to estimate binding and complexation stability
• Phase solubility studies as the experimental check on the computed prediction
Other Masking Strategies
• Ion exchange resinates, polymer coating and lipid barriers compared
• Prodrug and salt selection where the molecule permits it
• Release requirements that a masking approach must not compromise
Proving the Mask Works
• Electronic tongue measurement and its correlation with human panels
• In vitro dissolution in simulated saliva as a screening assay
• Human taste panel design, ethics approval and the limits of small panels
Technical Specifications
| Parameter | Requirement |
|---|---|
| Covered Tool / Platform | AutoDock Vina |
| Covered Tool / Platform | PyRx |
| Covered Tool / Platform | Schrödinger Suite |
| Covered Tool / Platform | GROMACS |
| Covered Tool / Platform | ChemDraw |
| Covered Tool / Platform | Discovery Studio |
| Covered Tool / Platform | ADMET Predictor |
Frequently Asked Questions
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